Dr. Leah Zagore earned her Ph.D. in Biochemistry, focusing on regulatory RNA binding proteins (RBPs) in the context of male germ cell development. She applied a multidisciplinary approach integrating transcriptome profiling tools (such as CLIP, RNA-seq, and ribosome profiling) with transgenic mouse and cell culture models to interrogate the function of the germ cell-specific RBP DAZL. Her results showed that DAZL functions as a master regulator of a post-transcriptional mRNA program essential for germ cell survival. During her postdoctoral training, Dr. Zagore continued to study RNA regulatory networks and worked to identify novel RBPs important during early T-cell activation. Dr. Zagore feels fortunate to have been involved with the development of new technologies in cell and RNA molecular biology. First, she helped develop an approach to enable kinetic analysis of RNA-protein interactions in cells using a pulsed femtosecond laser (KIN-CLIP). Importantly, this technique showed that global, in vivo kinetic parameters of RBPs could be measured and used to link protein-RNA binding to cellular RBP function. She also helped create a strategy combining dual fluorescence Cre-lox technology with flow cytometry to discriminate and isolate germ cells in different stages of development.

Banu Tamilselvan is a Biochemist with more than 18 years of experience in teaching, research, and lab management. Banu has received extensive training on 10x genomics platforms, and experience with a broad variety of cellular and molecular biology techniques and a variety of Next Generation Sequencing sample preparation. She is very curious and passionate about genomics technologies since the field is ubiquitous and promising for personalized medicine and novel therapeutic discovery for many other life-threatening illnesses. She is very happy to help clinician scientists and basic biology researchers apply cutting-edge tools to their research programs to advance their discoveries.

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