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Check out the latest publication from the Cameron Lab


In a collaboration with Dr. Brian Gastman's group, we investigated the transcriptional profile of terminally exhausted, tumor infiltrating T-cells from melanoma and squamous cell carcinoma patients. We discovered bile acid and peroxisome pathways and mTOR signaling are dysregulated in exhausted T-cells with high expression of immune checkpoint receptors. These pathways represent new immunotherapy targets that may help rescue the immune response to tumors.






Yorumlar


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Case Western
Reserve University

Applied Functional Genomics Core/ Cameron Lab
Case Western Reserve University
2123 Adelbert Rd., Wood Research Tower, RT100-5 Cleveland OH, 44106-2624
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